Cambridge Enterprise works in collaboration with University of Cambridge researchers to market and license technologies ranging from the biosciences to engineering.
Licensing Cambridge innovation
Cambridge Enterprise has completed close to 900 technology transfer transactions. We welcome contact from companies interested in licensing technologies from the University of Cambridge, and work with companies on an individual basis to identify specific areas of interest.
Researchers in the Department of Engineering have discovered a technique for building a low voltage liquid crystal scattering device which can be simply manufactured and does not require the use of polarisers. These advantages enable the use of the device as a low cost screen for hand held displays, not only by reducing the component and fabrication costs but also by improving the lifetime of both the screen itself and the battery powering the display.
In addition, the device's electrodes transmit across a broad range of the light spectrum (visible to infra-red) and can easily be fabricated on flexible or curved substrates to explore wider liquid crystal applications e.g. smart LC contact lenses.
A UK priority patent application has been filed to protect the technology, and we are now looking for companies who would like to work with us to develop this technology into a commercial offering.
Antibodies can usually be obtained against a wide variety of antigens however weakly immunogenic epitopes such as membrane proteins, highly conserved proteins and disordered proteins still pose a challenge. This has particular relevance when developing antibodies against disordered proteins such as αβ peptide, α-synuclein and islet amyloid polypeptide which are associated with Alzheimer’s, Parkinson’s and Type II diabetes respectively. Using a computational approach a team of scientists led by Professor Michele Vendruscolo of the University of Cambridge, has developed a method which allows the design of antibodies to target specific epitopes within a protein particularly disordered epitopes. Using this method, antibodies against αβ peptide, α-synuclein and islet amyloid polypeptide have been generated which bind with good specificity and affinity to the target protein. The method can be used to aid the development of therapeutics or probes directed against protein molecules of biomedical or biotechnological interest.
Using a computational approach a team of scientists led by Professor Michele Vendruscolo of the University of Cambridge, has developed a neural network method that can predict the solubility of a protein from the amino acid sequence and propose specific amino acid substitutions and/or insertions which will alter the solubility of the protein, while preserving its structure and functionality. The output is a short list of mutational variants with predicted solubility, or aggregation propensity, better than that of the protein provided as input. This method allows rapid screening of tens of thousands of mutations decreasing the time, cost and risk associated with the selection and development of candidate therapeutics and is of particular relevance for the development of therapeutics for high concentration subcutaneous formulations.
Bone fractures and osteoarthritis, particularly non-union fractures are of huge clinical and financial impact. Biomaterial grafts can aid bone repair, however a clinical need persists for superior treatment of bone damage. Human mesenchymal stem cells (hMSCs) could provide an ideal solution for bone repair, however for routine clinical use, cells must be stored and transported and current cryoprotection methods, such as freezing with DMSO, have raised toxicity concerns and may not receive regulatory approval.
Scientists at Cambridge and Edinburgh Universities have demonstrated that a new, non-toxic method of freezing hMSCs can successfully preserve cells when combined with a bone scaffold. This method therefore offers a potential new therapy for bone repair.
Encapsulation technologies can be used as delivery systems for a variety of applications in beauty, personal care, food and healthcare. Encapsulation provides a means of targeting delivery, protecting unstable actives from degradation, formulating incompatible actives and in controlling release and bioavailability. Using microfluidics emulsification a team of scientists, led by Dr Tuomas Knowles of the University of Cambridge, have developed a method of forming nanofibrillar protein microcapsules. These protein microcapsules have several advantages over existing encapsulation techniques:
- the capsules are resistant to heat, pH, proteases and physical forces;
- the capsule formation does not use cross linking agents or synthetic polymers;
- capsule morphology and release characteristics can be controlled by adjusting production parameters;
- the capsules are biocompatible and biodegradable; and
- the capsules can be formed from all types of protein.
The unique properties of natural silk, including strength, elasticity and biocompatibility have driven the development of functional silk based biomaterials, however native silk is a challenging substrate to process due to its high viscosity and propensity to aggregate and therefore current use of silk for biomedical application is based on recombinant or reconstituted silk. Using a microfluidics based strategy a team of scientists, led by Dr Tuomas Knowles of the University of Cambridge have developed a method to pattern native silk into microgel structures. These silk microgels can be used as a means to store native silk for several months without aggregation, whereas currently native silk is only stable for a few hours. Native silk has direct uses in medical devices, beauty and personal care and textiles. The silk microgels could also be used as a biocompatible encapsulation method for delivery of active ingredients.
Cell separation technology plays an important role in the fields of microbiology, biotechnology and bioscience, which have wide applications in the pharmaceuticals and healthcare industries. Existing methods suffer disadvantages of time, cost and scalability and, when antibodies are used to bind exogenous cell surface markers for magnetic selection, typically yield cells coated with antibody-antigen complexes and beads. A team from the University of Cambridge has developed a method for Antibody-Free Magnetic Cell Sorting of transfected or transduced cells that have several advantages:
- Positive selection of “untouched” cells
- Target gene overexpression or knockdown
- Enrichment following CRISPR/Cas9 genome editing
- No requirement for antibodies
- No restriction on cell type or species
- Simple, fast and cost-effective
Synergistic effect of 5-HT2c receptor agonist with marketed drug for treatment of obesity & diabetes
Prof. Lora Heisler has identified the synergistic effect of combining a selective 5-HT2C receptor agonist with a marketed off patent drug (of which there are several in its class) with excellent potential for improved treatment of obesity and type 2 diabetes with a low side effect profile.
Pharmaceutical drugs are typically either crystalline or amorphous. Thermodynamically, amorphous solids have a higher solubility and bioavailability compared to their crystalline counterparts, but they are inherently unstable and will crystallise with time. Ensuring high solubility of products is particularly important in the pharmaceutical industry. At present 40% of all lead compounds will not reach the market due to poor solubility. However, amorphous drugs are usually avoided, as it is impossible to reliably predict their stability using current technologies. Researchers at the Department of Chemical Engineering and Biotechnology have developed a spectroscopic method for quantitative stability analysis based on molecular dynamics at terahertz frequencies which could be used to predict the stability/shelf-life of amorphous molecules thereby increasing the efficiency in selecting suitable lead compounds during the drug development phase.
Scientists as Cambridge have developed a new method for determining embryo viability for in-vitro fertilisation (IVF).
This is a non-invasive and quantitative way of assessing key processes that affect embryo vitality, which could potentially improve the efficiency of IVF by identifying the best embryos to transfer to the mother.
Scientists at the University of Cambridge have designed and manufactured a tri-leaflet heart valve made of polymers and mimicking for the first time the unique anisotropic properties of natural tissue valves. This technology combines the durability of mechanical valves and the haemo-compatability and flexibility of natural tissue valves to offer new, improved heart valves.
Program for synthesis of Wavelength-Dispersive Electron Probe Spectra. This program allows the synthesis of wavelength-dispersive spectra, using stored experimental spectra, to facilitate the selection of optimal positions for background measurements and assist in the choice of suitable counting strategies for specific analytical situations.
Further information can be found at the Department of Earth Sciences website and in the following publications:
- Reed, S. J. B. and Buckley, A. (1996). Virtual WDS. Mikrochim. Acta (Suppl), 13, 479-483.
Reed, S. J. B. and Buckley, A. (1998). Computer simulation applied to WD analysis. Microscopy and Microanalysis, 4 (Suppl 2), 236-237.
Licenses to this software for both academic and commerial users are available for purchase by contacting us at email@example.com
An academic demo version of the software can also be found here.
Prof Judith Driscoll has developed a new electrolyte material that will enhance solid oxide fuel cells by allowing them to operate at much lower temperatures than is currently possible, allowing much more practical use. This electrolyte has an ionic conductivity two orders of magnitude greater than the current standard, while being simple and low-cost to manufacture. We are seeking a partner to help us demonstrate this material in a fuel cell. Please get in touch for more information.
A new method for low cost, high yield and quality graphene has been developed. It is envisaged that the electrochemical method could be readily scaled up using a multi-electrode cell with planar electrodes to produce 10kg/day which is more than current methods of chemical vapour deposition and exfoliation.
- Cost per tonne could be reduced by over two orders of magnitude
- Very high production rate compared to existing methods
- Very high quality graphene as shown by SEM image below
Cambridge scientists have developed a method to generate platelets in a test tube from stem cells or iPS cells. These cells provide opportunities for research and clinical application.
Scientists have developed a novel approach for directing the differentiation of embryonic stem cells by manipulating the cell cycle. Using cell cycle inhibitors in human pluripotent stem cells, this method gives rise to endoderm cells, which can further be differentiated into pancreatic beta cells or liver cells.
Cambridge University scientists have designed a new method of generating iPS cells using blood derived endothelial progenitors as a substrate. This method proves to be far more efficient than traditional methods of iPS cell differentiation, allowing rapid expansion in culture and large scale production.
Drs Ludovic Vallier and Nicholas Hannan have developed a novel, precisely defined and stepwise method to differentiate human pluripotent stem cells into a multipotent population of foregut stem cells. Not only can this culture system be expanded in 2D culture in the absence of a feeder population or scaffolds and is compliant with large scale production but the pluripotent cells obtained are truly multipotent and can produce at least three different cell types: lung, pancreas and liver.
Structural colour is the effect seen in opal gemstones, peacock feathers and butterfly wings, where a regular nanostructure within the material causes light of specific wavelengths to be selectively reflected. By contrast, traditional methods of generating artificial colour rely on of dyes or pigments, which can be toxic, prone to bleaching by UV, or subject to other surface-level degradation.
Researchers in the Department of Physics have been exploring the behaviour of thin layers of noble metals such as gold, silver or copper coated onto elastomeric films containing nanometre scale voids. The interaction of these films with light results in selective absorption and hence structural colour which can be tuned by bending, stretching or applying an electric field. The techniques are believed to offer relatively low cost, scalable manufacturing processes which can be applied in a wide range of applications requiring novel colour behaviour in very thin coatings. These coatings could be applied to injection moulded items, fabric, films or any other solid format (e.g. http://www.wired.com/2013/11/weird-nanophotonic-materials/#slideid-309831).
The technology is protected by a granted US patent and is undergoing examination in Europe.
We are now looking for companies who wish to work with us to develop the technology into something more commercially applicable. If you would like to find out how you can work with us please get in touch using the contact details provided.
Many conflict situations, ranging from extremist activities to intra-organisational disputes, arise from an inability to engage with different viewpoints. Integrative complexity (IC) is a capacity which can be developed to enable individuals to move away from “black and white” or “them and us” thinking. Conflict as a zero-sum game is overcome by the IC method, developed as a means to expand the way people think while concurrently remaining true to their own values.
The ICthinking® team at the University of Cambridge (Dr Sara Savage, Dr Jose Liht, Dr Eolene Boyd-MacMillan and others) have developed a unique methodology (ICthinking®) for increasing the IC of an individual, through
- carefully structured courses developed for specific conflict environments
- leveraging the ability for each participant to consider the conflict from a range of viewpoints while also increasing their awareness of the breadth of their own values.
All courses and training are research- and evidence- based, with findings on the whole range of different IC courses to date showing a consistent increase in participants’ IC level regarding ‘hot’ issues of conflict from black and white, polarised thinking to an ability to perceive some validity in opposing viewpoints, and to apply that to win/ win problem solving after just 16 hours of ICthinking® training.
More information on the courses offered and research context can be found on the ICthinking® website at http://www.ictcambridge.org/ or please contact Cambridge Enterprise for information on how you or your organisation can work with the ICthinking® team.
Researchers in the Department of Chemical Engineering and Biotechnology, have developed a novel method of encapsulating enzymes in a releasable manner. Using colloidosomes and a chemical shell, enzymes can be successfully encapsulated in a protective environment and released by shear or dilution, maintaining enzymatic activity. The capsule size and level of protection can be adjusted to allow triggered release when desired. This technology has been tested for the application of using enzymes in washing detergents with enzymes having been shown to be stable for long periods of storage. The method could have wider applications in the protection of other beneficial ingredients.
Optical diffusers are typically either mass produced by sandblasting glass, resulting in low cost devices with roughly uniform diffusion, or engineered holographic diffusers offering beam shaping but at a higher cost point.
Researchers at the University of Cambridge have developed a new optical diffuser material which offers a broader diffusion pattern (up to 30° Full Width Half Maximum) than the sandblasted device in conjunction with some degree of beamshaping using simple common manufacturing processes.
Performance is not significantly dependent on transmission wavelength in the visible wavelength range, with <5% variation in total transmitted light seen between 450 and 650 nm.
Fundamental thermal characteristics of the material also allow high temperature operation to ~500°C without the need for additional treatment such as chemical or UV protection.
E.coli is a key production host for chemical feedstocks based on renewable inputs. Achieving acceptable production economics is crucial. Introduction of a patented mutation enables induction of quiescence using indole to drive accumulation of any metabolite of interest rather than unwanted biomass. This process innovation enables biorefining at reduced cost of goods sold.
Childhood Autism Spectrum Test (CAST) is a questionnaire developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. Consisting of thirty seven questions, it aims to identify children aged 4-11 years who are at risk of having Asperger syndrome (AS) and related social and communication conditions. A suite of tests developed by the team for diagnosing autism found at the following link are also available for licensing: http://www.autismresearchcentre.com/arc_tests
The General Practice Assessment Questionnaire (GPAQ) is a patient questionnaire that helps practices find out what patients think about their care. It specifically focuses on aspects of general practice that are not covered elsewhere in the Quality and Outcomes Framework - for example, access, inter-personal aspects of care and continuity of care.
Printable electronics have to date been limited by the lower electron mobility and hence operation speed of organic materials compared to silicon, the production cost, processing requirements and performance of metal or carbon nanoparticle-based inks. Current generation transparent and electrically conductive layers are stiff and brittle and hence limit flexible electronic applications.
Professor Andrea Ferrari and his team in the Department of Engineering at the University of Cambridge have developed a novel method of ink production based on layered nanomaterials such as graphene. This technology overcomes the issues of current printable inks and can be printed by various methods on flexible substrates.
Calculating the minimum lap or manoeuvre time of a road vehicle has received much attention in the past. Existing solutions to the calculation problem include the quasi-steady-state method (QSS), which is computationally fast but ignores the transient dynamics of the vehicle and does not allow the optimum vehicle path to be determined. At the other end of the spectrum, nonlinear optimisation has been used, but there are associated difficulties with numerical robustness and computational load.
Researchers in the Department of Engineering have developed an algorithm which overcomes these limitations and provides a computationally efficient and numerically robust solution by formulating the problem as a convex optimisation. Given a set of vehicle parameters and road boundary geometry, the algorithm calculates the optimum path, speed, steering and drive/brake controls to minimise the lap or manoeuvre time of the vehicle. The results from the software have been validated against results from a nonlinear optimisation algorithm. Use of the software requires the industry-standard MATLAB® program and access to a Quadratic Programme Solver.
The software has application in the automotive and racing car industries.
Thermocouples for temperature measurement at high temperatures suffer drift over time due to atomic migration. Researchers at the University of Cambridge have developed a thermocouple sheath of unique design which significantly reduces high temperature drift. This both improves the accuracy of temperature measurement, and increases the durability of thermocouples.
This technology is applicable in many sectors including power generation, aerospace, heat treatment (of aerospace and other components), and automotive (turbochargers). Cambridge Enterprise is already collaborating with manufacturers and is seeking licensees with channels to market in each sector.
Professor Ian White and members of his research team in the Department of Engineering at the University of Cambridge have developed a technique for enabling simultaneous bi-directional transmission on standard multimode optical fibre. Signal rates of 10Gb/s have been demonstrated, resulting in an aggregate data rate of 20Gb/s without the need for multiple fibres. This also enables a duplex bi-directional optical link with an aggregate data rate of 40Gb/s.
This solution is protected by a granted US patent US8326157. CE would be interested to hear from companies looking to extend their data rates over multimode fibres in areas such as campus networks, data centres, storage area networks, enterprise LANs and other fields requiring high speed multimode fibre links.
Researchers from the University of Cambridge have developed a digital signal processing solution which overcomes the current limitations of in-building wireless signal propagation for advanced services such as 3G and LTE. Most large buildings requiring improved in-building radio coverage, such as shopping malls and airports, are installing Distributed Antenna Systems (DAS) which require dedicated high-specification infrastructure such as optical fibre, high linearity and dynamic range, and suffer from high energy consumption. Femtocells provide an alternative solution which avoid some of these issues but are still restricted to single service and fixed configurations.
The proposed digital DAS (DDAS) solution substantially compresses the data signals thereby reducing the infrastructure bandwidth requirement ultimately towards use of copper rather than optical fibre and also allowing multiple services (voice, data, video…) to be combined onto a single infrastructure. The use of DDAS also enables more flexible architectures, including per-service or per stream reconfigurability and remote service distribution for multiple buildings over a common infrastructure. This would allow easier upgrade and secure maintenance using software rather than the current hardware approach.
We are now looking for industrial partners to help us develop this technology further to exploit the exciting market opportunity which this technology presents.
Typically there is a trade-off to be made between the cost of an RFID tracking system and the coverage and tag locating capabilities which can be achieved. Most systems capable of reading tags with near 100% success rate over distances up to 100m require active tags to achieve their long range and high resolution location accuracy. Alternatively passive systems with cheaper tags, are limited to a reliable tag detection range of only a few meters.
Now researchers from the University of Cambridge have developed a system using passive tags and advanced signal processing which can achieve comparable tag detection performance to active tags at a lower cost point. This enables near 100% read success and has been demonstrated for asset tracking over a 20x20m2 area, although the system can readily scale to larger areas. The researchers have also demonstrated the potential of the technique for accurate real time location capabilities.
This technology is protected by patent applications in US, Europe and China, and is now ready for pilot commercial applications such as inventory and asset tracking and monitoring patient movement in hospitals.
Empathy Quotient (EQ), Systemizing Quotient (SQ) and Empathy/Systemizing Quotient (EQ-SQ) are questionnaires developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. They aim to test if adults, adolescents or children of average intelligence have Asperger syndrome or high functioning autism. A suite of tests developed by the team for diagnosing autism found at the following link are also available for licensing: http://www.autismresearchcentre.com/arc_tests
The Quantitative Checklist for Autism in Toddlers (Q-CHAT) is a questionnaire developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. Consisting of twenty-five questions, it aims to identify children aged 18-24 months who are at risk of having social-communication disorders. A version with 10 questions is also available. A suite of tests developed by the team for diagnosing autism found at the following link are also available for licensing: http://www.autismresearchcentre.com/arc_tests
The Autism Spectrum Quotient (AQ) is a questionnaire developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. Consisting of fifty questions, it aims to test if adults, children or adolescents of average intelligence have symptoms of autism or one of the other autism spectrum conditions. A suite of tests developed by the team for diagnosing autism found at the following link are also available for licensing: http://www.autismresearchcentre.com/arc_tests
In recent years, there has been an increasing interest in vibration energy harvesting, especially to enable self-powered wireless sensor networks for structural health monitoring. While some early commercial solutions have witnessed increasing deployments, two of the key technical limitations still stubbornly persist; namely, the low power density relative to conventional power supplies and the mis-match between the narrow operational frequency bandwidth of conventional energy harvesters and the wideband nature of real vibrations. Researchers at the University are addressing these issues through employing vibration energy harvesting based on auto parametric resonance rather than the conventional approach of using the fundamental mode of resonance.
Bulk acoustic wave (BAW) sensors based on micromechanical systems (MEMS) offer significant advantages over quartz crystal microbalance (QCM); such as compact size, compatibility with electronics, lower power consumption, lower cost and higher reliability. However, their wide application to real-world detection remains limited by the temperature-dependence of their performance. Recently researchers at the University of Cambridge have developed a novel Film Bulk Acoustic Resonator (FBAR) device which has the potential to overcome this limitation by enabling the simultaneous measurement of temperature and mass loading in a single device without increasing their size or adding complexity to the electronics. Through the use of a novel multi-layer device structure and electrode materials, temperature self-referenced FBAR resonators with high operating frequencies (~1-2 GHz) and world-leading Q-factors (>1500) have been produced paving the way for real-world monitoring using FBAR sensors.
Benefits and applications:
- Suitable for multiplexing for multiple analyte monitoring
- Liquid and gas phase sensing
- Small size (~150×150μm)
- Ultrahigh sensitivity (~10–15 g)
- Tuneable frequency of operation (suitable for >0.5 – 3 GHz applications)
- Low power consumption (µW)
- No environmental control required
Without using dyes or other applied colourants, polymer opals reflect specific colours due to their physical structure. By choosing the spacing of tiny polymer spheres which make up the material, the colour can be tailored to any colour in the rainbow. Stretching the material changes that spacing – and also the colour. So a sample of polymer opal material might stretch from red to green and then blue, reversibly relaxing back to its original colour. Colour changes can even be localised to reveal a pattern such as a logo on stretching.
Researchers at the University of Cambridge, working with colleagues at the LBF Fraunhofer Institute in Darmstadt (formerly DKI), have developed this material system and its manufacturing process so that polymer opals can now be produced in an industrially scalable way and laminated simply onto any appropriate substrate, including fabric, for applications such as security, brand protection and clothing. We are now actively seeking a partner to take this process to the next stage and would welcome contact from companies with interest or experience in this area.
Please see the linked documents for technical information and a more visual demonstration of polymer opals’ colour behaviour.
CAM2 is a new fitting software package that enables hearing aids to be tailored to an individual’s needs, resulting in improved hearing quality. All modern hearing aids include multi-channel amplitude compression and the characteristics of the compression need to be set to suit the individual hearing-impaired person. CAM2 has been developed to provide a superior solution for the tailoring of wide-band hearing aid parameters, using the audiogram alone and is an essential new tool in the audiology field.
CAM2 is available for licensing to hearing aid manufacturers and providers and for academic research purposes. If you are a hearing aid user interested in having CAM2 used in the fitting of your hearing aid, please contact your hearing aid provider and ask them to get in touch with us directly.
A stable human cell line expressing multiple copies of biotinylated ubiquitin under tight control by tetracycline. This cell line enables clean and easy identification and quantification of ubiquitin substrates, studies of ubiquitination mechanisms and ubiquitination inhibitor screens. Ubiquitination is thought to be a key signaling mechanism in diseases such as cancer and these cells will be a powerful tool for the ubiquitin research community.
Recordings of speakers with ‘Standard Southern British English’ pronunciation have been collected and transcribed orthographically by researchers in the Department of Theoretical and Applied Linguistics at the University of Cambridge.
The database was recorded with forensic phonetic research in mind, but serves very generally as an extensive source of contemporary spoken English. It comprises studio quality recordings of 100 male speakers aged 18-25 performing four tasks involving different speaking styles: taking part in a simulated police interview, making a telephone call with an “accomplice” (recorded simultaneously and over the public telephone network), reading a passage, and reading a set of sentences.
Compared to alternative databases of comparable size, this database provides, for a tightly homogeneous population of speakers, a spectrum of speaking styles with a substantial number of words and phrases (elicited by design) in common. It is expected to be of interest to companies involved in a variety of speech technologies, and is available to license from the Economic and Social Data Service.
Thermoregulation is a new physiological indicator of athletic fitness that correlates with cardio-pulmonary fitness (VO2 max).
Thermoregulation improves during training and this provides the basis of a new type of fitness monitor. We have developed a wearable device to measure thermoregulatory fitness during an easy exercise protocol. The test can be completed by anyone from individuals just starting training through to elite athletes.
For more information see the publication:
Absolute power, not sex, promotes perspiration; Christof J. Schwiening, Matthew J. Mason and Martin Thompson; Experimental Physiology (2011) 96, 556-558.
Algorithm for switching between open and closed loop control as a safety mechanism for the artificial pancreas enabling insulin delivery if a closed loop artificial pancreas fails. Management of type 1 diabetes can be significantly improved through use of a closed loop which allows completely automated treatment. However, there are concerns over what happens if the artificial pancreas stops operating unexpectedly such as when sensor glucose becomes unavailable and this algorithm switches operation to a conventional "open" loop for safe insulin delivery when defects occur. This algorithm has been successfully used in "at home" clinical trials in conjunction with closed loop insulin delivery."
Administration of a recombinant protein known to be involved in preventing oxidative stress to preterm infants shortly after birth is therapeutically beneficial to protect against complications of prematurity and to reduce the costs of neonatal intensive case.
Origin-specific vascular smooth muscle cells were generated from both human embryonic stem cells and induced pluripotent stem cells using chemically defined media. These cells have now been shown to be pure (> 90%), mature and contractile for lineage-specific human cells disease modelling.
A novel drug-like series of 5-HT1B silent antagonists with excellent potential for treatment of pulmonary arterial hypertension (PAH) with a low side effect profile and in-vivo data showing reversal of PAH.
Executable and source code to represent glucose regulation of type 1 diabetes.
Enables exploration of mechanisms involved in glucose dependent insulinotropic polypeptide secretion with the potential to identify targets in these cells that could be exploited therapeutically for treatment of obesity.
Novel method to derive haploid mouse embryonic stem cells (ESC) for forward genetic screening. Several different haploid mouse embryonic stem cell lines are currently maintained, including from different mouse strains and transgenic lines. These cells have now been shown to be extremely useful for many applications, including novel gene identification in forward screens, generation of homozygous mutation libraries, identification of determinants of drug toxicity and introduction of desired mutations into mice. For more information on generation and use see:
The ICM+® computer program, developed by Dr Peter Smielewski and Prof Marek Czosnyka, provides for real-time multimodality monitoring, analysis and data storage in neurological intensive care environments. It is designed to augment clinical research but is not licensed for diagnostic, therapeutic or clinical decision-making purposes.
A non-exclusive licence with standard terms and conditions is available for the ICM+® software.
To obtain a licence tailored to your needs:
2. We will then send you a custom proposal for the licence (as well as custom consultancy work if requested).
3. If you wish to proceed, we’ll draft a licence (and consultancy agreement if requested) and send it to you.
4. The licence (and consultancy agreement if requested) will need to be signed by both an authorised official at your organisation and by the head of the research group requesting the software. Hard copies can be posted:
Cambridge Enterprise Limited
University of Cambridge
3 Charles Babbage Road
Depending on the terms of the licence, the ICM+® software can then be installed (either remotely or via an on-site visit) and you will then be invoiced thereafter.
5. Should you wish to continue downloading maintenance updates for the software after 2 years via the ICM+® website, then download the maintenance agreement and enter your organisation's name, full registered address (and VAT number if applicable) on page 1 of the agreement and follow the instructions as per (4) above, providing your contact details (name, job title, email, telephone) for subsequent invoicing. One day of remote support is provided along with the maintenance updates.
The ICM+® software is in a development stage and is provided “as is” (ie. it is not error-free). ICM+® is designed for research use only and is not designed for, or tested for providing information on which to base clinical decisions. ICM+® has not been approved for use by any regulatory authority.
Add-ons for ICM+® supplied by third parties:
- ICM+ Tools: a separate add-on tool called to assist with the management of data resulting from the use of ICM+® is available from Monash University.
- nICP plug-in: a separate plug-in for ICM+® that enables non-invasive calculation of ICP from TCD FV and ABP signals in real time is available from Bernhard Schmidt at Klinikum Chemnitz.
These two providers are listed strictly for information purposes only. Cambridge Enterprise accepts no responsibility for the use or quality of the software, goods or services provided by third parties.
JBIG-KIT is a software implementation of the JBIG1 data compression standard (ITU-T T.82), which was designed for bi-level high-resolution image data such as scanned documents. This library is available in portable C code and has been widely used in fax products, printer firmware and drivers, and document management systems. The package includes a variant implementation of just the ITU-T T.85 profile, with memory management optimized for embedded and fax applications.
The 'Inerter' is a novel passive device which allows designers of ride-control and suspension/damping systems the ability to realise performance levels that were previously only possible with actively controlled architectures. The device may be used on its own or in conjunction with traditional ride-control building blocks, to allow the designer cheap and simple, passive access to the full range of suspension characteristics. The device promises improvements over traditional technologies in areas such as passenger comfort, heavy vehicles dynamics and the handling of high-performance vehicles.
Enhancement of critical current densities by an order of magnitude in YBCO in self fields or applied fields with no lowering of the critical temperature. The enhancement, by incorporating rare earth tantalates into the YBCO, is effective even in thick films and over wide angular ranges of applied field.
Gaussian Approximation Potential (GAP) is a novel atomistic modelling technique that combines accuracy with speed. By inferring the energy of an atom from the position and identity of its neighbours using a precomputed database of exact quantum mechanical solutions, the potential energy surface of a system of atoms and molecules is approximated.
This methodology allows a controllable compromise to be made between the accuracy of Quantum Chemistry models and the speed of Interatomic Potential methods, with applications in a diverse range of fields including pharmaceuticals, aerospace, electronics and biotechnology.
Unlike currently existing endometriosis mouse models, this novel allograft model is an immuno-competant mouse that produces viable endometriosis-like lesions. This model will be useful in screening and identifying compounds for use in the treatment of endometriosis. Other applications include investigating the pathogenesis of endometriosis, identifying target genes or others factors associated with endometriosis.
High purity Activin A available in large quantities from E Coli, useful as an additive in stem cell culture and as a mesoderm inducer in developmental biology.
Human keratinocyte cell line useful in research related to human papillomavirus type 16 (HPV16) and cervical carcinoma.
Enables exploration of mechanisms underlying GLP-1, PYY and glucagon release, with the potential to identify targets in proglucagon-expressing cells that could be exploited therapeutically for the treatment of diabetes and obesity.
Large quantities of recombinant full-length human RAD51 useful for biochemical and biological assays including for DNA strand exchange, protein-protein/protein-DNA interaction studies in vitro and in vivo and Western blots.
A novel agent for use in molecular imaging of apoptotic cells that can be cross-linked to a variety of contrast agents and is highly suitable for use with imaging technologies such as MRI, PET and SPECT. This imaging agent may be useful as a prognostic indicator of treatment outcome for cancer or cardiac plaque formation.
Our researchers have identified the earliest known marker for DNA damage. Phosphorylation of residue Thr51 of protein HP1β occurs within minutes of the onset of DNA damage. A robust, specific polyclonal antibody to the phosphorylated form of this protein has been developed which is an effective biomarker for DNA damage. This has excellent potential for use as a biomarker in clinical applications such as the diagnosis, prognosis and predictive response of individuals to cancer therapy.
Novel controller for navigation of 3D medical imaging data that enables interactive 2D reformatting of, and navigation through, volumetric imaging data, such as data from CT or MRI, whilst avoiding visual distraction.
For more information see the video:
An ideal limb prosthesis is one that the patients can naturally wear and control. This can be achieved through the use of an implanted neural interface that records neuronal signals that can be used to control the prosthesis. The neural interface developed here allows damaged nerve fibres to regenerate through an array of electrode-coupled microchannels in a way that increases signal levels and decreases the incidence of crosstalk.
Two stable inducible rat phaeochromocytoma (PC12) cell lines expressing GFP-tagged exon 1 of the Huntington gene with either 23 or 74 glutamine repeats (PC12 HD-Q23 or PC HD-Q74), driven by a doxycycline-dependent Tet-On promoter. These cell lines can be used for in vitro studies to evaluate compounds to treat Huntington's disease.
Transgenic mice are engineered so that on induction they rapidly and predictably develop a disease state that shares major features of advanced vulnerable atherosclerosis in humans. This valuable model is highly suited to studies of cardiovascular drugs which stabilise atherosclerotic plaques and the long term study of arterial diseases such as aneurysm formation, angioplasty restenosis and atherosclerosis.
A method for predicting prognosis in autoimmune diseases including lupus and ANCA-associated vasculitis. The technique enables patients to be divided into groups at high and low risk of disease progression to identify patients requiring intensive immunosuppressive therapy or to reduce the total immunosuppressive load in patients at low risk of disease relapse.
Novel, improved, human, antibody constant regions which lack destructive effector functions. These constant regions can be combined with the variable region genes or receptor domains of your choice to produce antibodies or fusion proteins of any desired specificity. Specific applications in the areas of autoimmunity, inflammation, allergy, asthma and cardiovascular disease are envisaged. Recent in-man studies have demonstrated that these modifed constant regions can produce a less destructive, but highly efficacious antibody for the treatment of fetomaternal alloimmune thrombocytopenia.