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Hybridoma cell line producing IR 83-12 antibodies raised against the extracellular domain of the human insulin receptor, which are mouse monoclonal antibodies of the IgG1 isotype. Has been shown to cross react with bovine, porcine, ovine and rabbit, but not with rat or mouse insulin receptors. It has been shown to enhance insulin binding and has been used in immunoprecipitation assays.

Publications:

Biochem J (1986) 235, 199

Biochem J (1987) 242, 123

EMBO J (1987) 6, 4003

Biochem J (1990) 268, 615

J Biol Chem (1990) 265, 9970. www.jbc.org/

J Biol Chem (1990) 265, 13248. www.jbc.org/

PNAS (1991) 88, 9858. www.pnas.org/