Hybridoma cell line producing IR 18-34 antibodies raised against the extracellular domain of the human insulin receptor which are mouse monoclonal antibodies of the IgG2a isotype. Has been shown to cross react very weakly with bovine, porcine and ovine but not rabbit, rat or mouse insulin receptors. It has been shown to cause up to 50% inhibition of insulin binding and has been used in immunohistochemistry, immunoprecipitation and blocking assays.

Publications:

Biochem J (1986) 235, 199

Biochem J (1987) 242, 123

EMBO J (1987) 6, 4003

Biochem J (1990) 268, 615

J Biol Chem (1990) 265, 9970. www.jbc.org/

J Biol Chem (1990) 265, 13248. www.jbc.org/

PNAS (1991) 88, 9858. www.pnas.org/