Herpes Simplex Virus Type 1 and 2 (HSV-1 and -2) Glycoprotein D monoclonal antibody LP2 (anti-HSV gD)

Code: AB88

Hybridoma cell line producing LP2 antibodies raised against Herpes Simplex Virus Type-1 and Type-2 envelope protein Glycoprotein D, which are mouse monoclonal antibodies of the IgG2a isotype. Strongly neutralises virus in the absence of Complement. Works well for immunofluorescence (IF) on fixed specimens and for immunoprecipitiation (IP) on triton solubilised samples. Does not work in western blots. The antibody epitope is well characterised by binding competition assays and by sequencing of antibody escape mutants.

Publications:

Minson A.C., Hodgman T.C., Digard P., Hancock D.C., Bell S.E., Buckmaster E.A.
An analysis of the biological properties of monoclonal antibodies against glycoprotein D of herpes simplex virus and identification of amino acid substitutions that confer resistance to neutralization.
J Gen Virol. 1986 67:1001–13.
http://vir.sgmjournals.org/

Buckmaster E.A., Cranage M.P., McLean C.S., Coombs R.R., Minson A. The use of monoclonal antibodies to differentiate isolates of herpes simplex types 1 and 2 by neutralisation and reverse passive haemagglutination tests.
J Med Virol. 1984 13:193–202.
http://eu.wiley.com/WileyCDA/WileyTitle/productCd-JMV.html

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