Hybridoma cell line producing IR 83-22 antibodies raised against the alpha subunit of the human insulin receptor, which are mouse monoclonal antibodies of the IgG1 isotype. Has been shown to cross react very weakly with bovine, porcine and ovine, but not rabbit, rat or mouse insulin receptors. It has been shown to cause >80% inhibition of insulin binding and has been used in immunoprecipitation and blocking assays.

Publications:

Biochem J (1986) 235, 199

Biochem J (1987) 242, 123

EMBO J (1987) 6, 4003

Biochem J (1990) 268, 615

J Biol Chem (1990) 265, 9970. http://www.jbc.org/

J Biol Chem (1990) 265, 13248. http://www.jbc.org/

PNAS (1991) 88, 9858. www.pnas.org/