MOCHA Mouse Skin Fibroblast Cell Line

Code: CL-0385

MOCHA is a naturally occurring mouse mutant with a null mutation in the delta subunit of AP3 complex. In MOCHA cells, the ß3 and μ3 subunits co-assemble into a heterodimer whereas the σ3 subunit remains monomeric. The mouse has a similar phenotype to the human genetic disorder, Hermansky Pudlak Syndrome (HPS). In both mice and humans, AP3 deficiency results in hypopigmentation because of abnormalities in melanosomes. The MOCHA mouse skin fibroblast cell line can be used to investigate the assembly of AP3 complexes and AP3 function.

J. Cell Biol. 2002, 156, 327-336.

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