Hybridoma cell line producing 2AC5 antibodies raised against human brain creatine kinase which are mouse monoclonal antibodies of the IgG1 isotype. Useful for diagnosing tissue injury, especially myocardial infarction and potentially useful as a marker for head injuries, some neurological disorders and certain malignancies. Can also be used to generate a specific and sensitive assay for brain creatine kinase.
Jackson, A. P., Siddle, K., and Thompson, R. J. Two-site monoclonal antibody assays for human heart- and brain-type creatine kinase. Clin Chem, 30: 1157–1162, 1984. www.clinchem.org/
Jackson, A. P. and Thompson, R. J. The stability of creatine kinase isoenzymes studied with two-site monoclonal antibody assays. Ann Clin Biochem, 22 ( Pt 3): 310–315, 1985.
Rossi, R., Ekroth, R., Lincoln, C., Jackson, A. P., Thompson, R. J., Scallan, M., Tsang, V., Jackson, A., and Thompson, R. Detection of cerebral injury after total circulatory arrest and profound hypothermia by estimation of specific creatine kinase isoenzyme levels using monoclonal antibody techniques. Am J Cardiol, 58: 1236–1241, 1986. www.ajconline.org
Thompson, R. J., Jackson, A. P., and Langlois, N. Circulating antibodies to mouse monoclonal immunoglobulins in normal subjects–incidence, species specificity, and effects on a two-site assay for creatine kinase-MB isoenzyme. Clin Chem, 32: 476–481, 1986. www.clinchem.org/Make an Enquiry