Available technologies

Licensing Cambridge innovation

Cambridge Enterprise works in collaboration with University of Cambridge researchers to market and license available technologies ranging from the biosciences to engineering.

We have completed more than 1,000 commercial agreements.

We welcome contact from companies interested in licensing available technologies from the University of Cambridge, and work with companies on an individual basis to identify specific areas of interest.

Image: The chromosome screening technology developed by University of Cambridge spin-out BlueGnome has shown to increase in vitro fertilisation (IVF) success rates by 65% over the current methods.

Method to increase in-vitro production of platelets

Life sciences Ref No: Ghe-3579-18
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  • A method using soluble factors able to induce an acute release of platelets from megakaryocytes (MKs) in-vitro prior to harvest.
  • Tested in human cord-derived and iPSC-derived MKs.
  • Increase in platelet number up to 8 folds compared to untreated MKs.

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Hepatoblast Organoids – A novel 3D primary cellular model for drug screening and cell based therapy in liver

Life sciences Ref No: Val-3636-18
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University of Cambridge researchers have generated a unique human hepatoblast organoid system that can be maintained for more than a year in each line. The lines expand exponentially, demonstrate transcriptional and genomic stability, express key functional hepatic proteins and can be frozen down for long term storage. The HBO can be treated in vitro to differentiate towards cholangiocyte or hepatocyte lineages on demand. The HBO system offers two exciting areas of commercialisation: drug screening and cell-based therapy. The team are seeking a commercial partner for collaboration and development of this technology.

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Method for single nucleotide resolution mapping of abasic (AP) sites

Life sciences Ref No: Bal-3454-17
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Prof. Sir Shankar Balasubramanian and his team have developed a novel method for single nucleotide resolution mapping of AP sites (including endogenous sites) in genomic DNA. The method uses a novel probe, with selectivity >200 fold relative to 5-fU and >2000 fold relative to 5-fC for use in epigenetics research.

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Human-Sized Tubular Tissue Scaffolds

Life sciences Ref No: Mar-3702-18
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A team from the University of Cambridge has developed a novel method for generating human-size tubular tissue scaffolds, which have the potential to be used as a replacement for a range of diseased or damaged conduits in the human body. The scaffolds are made of biocompatible polymeric hydrogel materials, which support cell/organoid growth, whilst having sufficient mechanical strength for surgical implantation and offering the potential for luminal patterning. The scaffolds have been tested in-vivo. The team is seeking a commercial partner for collaboration and development of this technology.

 

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Enhancing the efficacy and persistence of adoptive T cell therapies

Life sciences Ref No: Joh-3155 & Joh-3733-19
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Apollo Therapeutics, working closely with Prof. Randall Johnson and his team in the Department of Physiology, Development & Neuroscience at the University of Cambridge have developed a small molecule that promotes memory T cell populations – octyl S-2-hydroxyglutarate – and have demonstrated applicability to human CAR-T systems.

 

Licensing opportunity: octyl S-2-hydroxyglutarate

  • Promotes memory T cell populations, conferring persistence and proliferation that translates into enhanced anti-tumour efficacy
  • Characterised in mouse and human systems
  • Fully compatible with human CAR-T lentiviral transduction protocols
  • Opportunity for clinical differentiation

 

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A New Class of Collagen Membranes

Life sciences Ref No: Cam-3575-17
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A new collagen membrane technology has been developed by Professor Ruth Cameron and Professor Serena Best and their team that has the potential to allow for a range of benefits, including:

  • Membranes produced to any size, texture and thickness
  • Curved, shaped, and seamless tubular membranes possible
  • Live cells can be embedded to speed recovery
  • Membranes may be command set in situ to suit the patient

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Polymeric heart valve

Life sciences Ref No: Mog-2514-10
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Scientists at the University of Cambridge have designed and manufactured a tri-leaflet heart valve made of polymers and mimicking for the first time the unique anisotropic properties of natural tissue valves. This polymeric heart valve technology combines the durability of mechanical valves and the haemo-compatibility and flexibility of natural tissue valves to offer new, improved heart valves.

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iPS cells derived from circulatory endothelial progenitors

Life sciences Ref No: Mor-2564-11
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Scientists at the University of Cambridge have designed a new method of generating iPS cells using blood-derived endothelial progenitors as a substrate. This method proves to be far more efficient than traditional methods of iPS cell differentiation, allowing rapid expansion in culture and large scale production.

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Childhood Autism Spectrum Test (CAST)

Life sciences Ref No: Bar-2844-13
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Childhood Autism Spectrum Test (CAST) is a questionnaire developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. Consisting of 37 questions, it aims to identify children aged 4–11 years who are at risk of having Asperger Syndrome (AS) and related social and communication conditions. A suite of tests developed by the team for diagnosing autism is also available for licensing.

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Empathy/Systemizing Quotient (EQ-SQ)

Life sciences Ref No: Bar-2748-12
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Empathy Quotient (EQ), Systemizing Quotient (SQ) and Empathy/Systemizing Quotient (EQ-SQ) are questionnaires developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. They aim to test if adults, adolescents or children of average intelligence have Asperger Syndrome or high functioning autism. A suite of tests developed by the team for diagnosing autism is also available for licensing.

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Quantitative Checklist for Autism in Toddlers

Life sciences Ref No: Bar-2747-12
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The Quantitative Checklist for Autism in Toddlers (Q-CHAT) is a questionnaire developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. Consisting of twenty-five questions, it aims to identify children aged 18-24 months who are at risk of having social-communication disorders. A version with 10 questions is also available. A suite of tests developed by the team for diagnosing autism are also available for licensing.

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Autism Spectrum Quotient (AQ)

Life sciences Ref No: Bar-2746-12
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The Autism Spectrum Quotient (AQ) is a questionnaire developed by Professor Simon Baron-Cohen and colleagues at the Autism Research Centre and available for licensing. Consisting of 50 questions, it aims to test if adults, children or adolescents of average intelligence have symptoms of autism or one of the other autism spectrum conditions. A suite of tests developed by the team for diagnosing autism is also available for licensing for commercial use.

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Generation of origin-specific vascular smooth muscle cells

Life sciences Ref No: Sin-2591-11
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Origin-specific vascular smooth muscle cells were generated from both human embryonic stem cells and induced pluripotent stem cells using chemically defined media. These cells have now been shown to be pure (> 90%), mature and contractile for lineage-specific human cells disease modelling.

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Simulator software

Life sciences Ref No: Hov-2295-09
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Executable and source code to represent glucose regulation of Type 1 diabetes.

 

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Transgenic mice with fluorescently labelled intestinal K-cells

Life sciences Ref No: Gri-2367-09
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This enables exploration of mechanisms involved in glucose dependent insulinotropic polypeptide secretion with the potential to identify targets in these cells that could be exploited therapeutically for treatment of obesity.

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Transgenic mice with fluorescently labelled proglucagon-expressing cells

Life sciences Ref No: Gri-1716-06
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This enables exploration of mechanisms underlying GLP-1, PYY and glucagon release, with the potential to identify targets in proglucagon-expressing cells that could be exploited therapeutically for the treatment of diabetes and obesity.

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Novel apoptosis imaging agent

Life sciences Ref No: Bri-2121-08
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This is a novel agent for use in molecular imaging of apoptotic cells that can be cross-linked to a variety of contrast agents and is highly suitable for use with imaging technologies such as MRI, PET and SPECT. This imaging agent may be useful as a prognostic indicator of treatment outcome for cancer or cardiac plaque formation.

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Novel controller for navigation of 3D medical imaging data

Life sciences Ref No: Lom-1613-06/Lom-2382-10
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Novel controller for navigation of 3D medical imaging data that enables interactive 2D reformatting of, and navigation through, volumetric imaging data, such as data from CT or MRI, whilst avoiding visual distraction.

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