Available reagents

Licensing for the research community

Cell lines, antibodies, proteins, DNA constructs, small molecules and other research tools generated by scientists at the University of Cambridge play a key role in laboratory research. There is a wide range of research reagents available for commercial licensing through Cambridge Enterprise. The selection is constantly changing, so please contact us directly with your specific needs.

Non-exclusive licences with standard terms and conditions are available for available reagents.

We are currently seeing increased interest in our research reagents portfolio as biotech companies respond to the COVID-19 crisis. You can read our blog on this topic here.

ISOLDE: Building High Quality Macromolecular Models into Low Resolution Experimental Maps

13 January, 2020 | Other Code: Cro-3730-19
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ISOLDE is a ChimeraX plugin (installable via its built-in Tool Shed) designed to ease the task of building high quality macromolecular models into low to medium resolution electron density maps where experimental information alone is insufficient to place individual atoms precisely. ISOLDE is unique in that it allows the model building task to be re-imagined as a truly interactive experience akin to working with a real physical molecule. It achieves this by combining the AMBER molecular dynamics forcefield (providing a high-fidelity description of the forces governing most macromolecules and small molecule ligands) with the GPU-accelerated molecular dynamics engine OpenMM, solving Newton’s laws of motion for these forces hundreds of times per second on systems of a few thousand atoms. Advantages of ISOLDE include real-time geometric validation, automatic fixing of simple errors thus reducing time spent on manual model building, and native compatibility with cryo-EM maps and/or crystallographic data. ISOLDE can generate maps directly from crystallographic F/sigF or I/sigI data in MTZ or CIF format (and automatically re-calculate them when the model changes), as well as “static” maps from pre-calculated F/phi data.

Further information can be found at the ISOLDE website and in the following publication:

Croll, Tristan Ian. 2018. “ISOLDE: A Physically Realistic Environment for Model Building into Low-Resolution Electron-Density Maps.” Acta Crystallographica Section D: Structural Biology 74 (6):519–30. doi: 10.1107/S2059798318002425.

Licences for academic (non-commercial) use are free of charge and terms of use are available on the ISOLDE website. Commercial software licences are also available for purchase by contacting us at the link below.

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Leukocyte Ig-Like Receptor (LILR) Mouse Model

1 February, 2016 | Other Code: OM-0227
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A transgenic Leukocyte Ig-Like Receptor (LILR) mouse model useful for exploring the function, expression pattern, and developmental regulation of the human Ig-like activating and inhibitory receptor Leukocyte Ig-Like Receptor. The LILR transgenes were expressed in a similar, but not identical, pattern to that observed in humans.

This mouse model has been described in:

J Immunol. 2003, 171(6), 3056-63.

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Herpes simplex virus type 1 strain SC16 thymidine kinase deletion mutant

5 September, 2011 | Other Code: OM8
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Human herpes simplex virus type 1 strain SC16 thymidine kinase deletion mutant, developed at the University of Cambridge. Useful in the study of antiviral drug resistance and the pathogenesis of thymidine kinase virus mutants.

Publications:

Journal of General Virology (1989) 70: 869–879. vir.sgmjournals.org/

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Human Serum-Resistance Associated Antigen

5 September, 2011 | Other Code: OM7
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Human Serum-Resistance Associated Antigen, potentially useful in the development of serodiagnostic for human infection with Tyrpanosoma brucei rhodesiense.

Publications:

Trends in Parasitology, 2004 20, 11, 519–523. http://www.cell.com/trends/parasitology/home

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ISG 75 Antigen (Invarient surface glycoprotein)

5 September, 2011 | Other Code: OM6
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Invarient surface glycoprotein (ISG 75) Antigen is a recombinant protein produced in E. coli corresponding to the extracellular domain of ISG75. Soluble to >5 mg/ml in the absence of detergents. Potentially useful in the development of a serodiagnostic for human or animal infection with Tyrpanosoma bruei.

Publications:

Trends in Parasitology, Vol 20, No 11 p519 Nov 2004. http://www.cell.com/trends/parasitology/

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ISG 65 Antigen (Invarient surface glycoprotein)

5 September, 2011 | Other Code: OM5
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Invarient surface glycoprotein (ISG 65) Antigen is a recombinant protein produced in E. coli corresponding to the extracellular domain of ISG65. Potentially useful in the development of a serodiagnostic for human or animal infection with Trypanosoma brucei.

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ISG 64 Antigen (invarient surface glycoprotein)

5 September, 2011 | Other Code: OM4
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Invarient surface glycoprotein (ISG 64) Antigen is a recombinant protein produced in E. coli corresponding to the extracellular domain of ISG64. Soluble to >5 mg/ml in the absence of detergents. Potentially useful in the development of a serodiagnostic for human or animal infection with Trypanosoma brucei.

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