Available reagents

Licensing for the research community

Cell lines, antibodies, proteins, DNA constructs, small molecules and other research tools generated by scientists at the University of Cambridge play a key role in laboratory research. There is a wide range of research reagents available for commercial licensing through Cambridge Enterprise. The selection is constantly changing, so please contact us directly with your specific needs.

Non-exclusive licences with standard terms and conditions are available for available reagents.

MOCHA Mouse Skin Fibroblast Cell Line

16 February, 2017 | Cell lines Code: CL-0385
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MOCHA is a naturally occurring mouse mutant with a null mutation in the delta subunit of AP3 complex. In MOCHA cells, the ß3 and μ3 subunits co-assemble into a heterodimer whereas the σ3 subunit remains monomeric. The mouse has a similar phenotype to the human genetic disorder, Hermansky Pudlak Syndrome (HPS). In both mice and humans, AP3 deficiency results in hypopigmentation because of abnormalities in melanosomes. The MOCHA mouse skin fibroblast cell line can be used to investigate the assembly of AP3 complexes and AP3 function.

J. Cell Biol. 2002, 156, 327-336.

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PC12 HD-Q23 (lines 14 & 7) and HD-Q74 (lines 10 & 1b) cell lines for Huntington’s Disease research

3 February, 2016 | Cell lines Code: CL4 and CL5 (Rub-1856-07)
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Two stable inducible rat phaeochromocytoma (PC12) cell lines expressing GFP-tagged exon 1 of the huntingtin gene with either 23 or 74 glutamine repeats (PC12 HD-Q23 or PC12 HD-Q74), driven by a doxycycline-dependent Tet-On promoter – these cell lines can be used for in vitro studies to evaluate compounds to treat Huntington’s Disease.

Download more information here.

Publications:

Wyttenbach et al. (2001) Hum Mol Genet. 10,1829-45.

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Stable human U2OS biotin-Ub cell line for ubiquitin research

22 June, 2015 | Cell lines Code: CL-0229
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A stable human U2OS biotin-Ub cell line expressing multiple copies of biotinylated ubiquitin under tight control by tetracycline. This cell line enables clean and easy identification and quantification of ubiquitin substrates, studies of ubiquitination mechanisms and ubiquitination inhibitor screens. Ubiquitination is thought to be a key signalling mechanism in diseases such as cancer and these cells will be a powerful tool for the ubiquitin research community.

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Macaca mulatta (Rhesus macaque)/ *Macaca fascicularis (Cynomolgus macaque) FcγRIIb expressing cell lines

23 April, 2015 | Cell lines Code: CL-0270
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Clone of CHO-K1 cells expressing * Macaca mulatta (Rhesus macaque) / *Macaca fascicularis (Cynomolgus macaque) FcγRIIb as a transmembrane protein.

*The sequence for the extracellular domains of FcγRIIb from Rhesus macaque (NP_001258577) and a predicted sequence for one polymorphic form of FcγRIIb from Cynomolgus macaque (NW_005092960) are identical at the amino acid level. There is one amino acid change (Leu104Met) relative to the Cynomolgus macaque sequence AAL92097.

Cambridge Enterprise Limited is the exclusive licensor this cell line. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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Papio anubis (Olive baboon) FcγRIIIa GPI expressing cell lines

23 April, 2015 | Cell lines Code: CL-0239
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Clone of CHO-K1 cells expressing *Papio anubis (Olive baboon) FcγRIIIa anchored to glycosyl-phosphatydylinositiol.

*Sequences predicted from NCBI NM_001112647.1 are identical at the amino acid level.

Cambridge Enterprise Limited is the exclusive licensor this cell line. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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HeLa-Mitotrap cell lines

7 January, 2015 | Cell lines Code: CL-0272, CL-0273, CL-0274 and CL-0275
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HeLa-Mitotrap, HeLa-Mitotrap-Ap1g1-FKBP, HeLa-Mitotrap-Ap2a2-FKBP and HeLa-Mitotrap-GGA2-FKBP are stably transfected cell lines. HeLa-Mitotrap expresses a mitochondrial trapping construct with an FRB domain and is maintained in hygromycin-containing medium. The other three cell lines also express Mitotrap, and in addition they express a protein of interest with an FKBP domain attached, which can be trapped onto mitochondrial when rapamycin is added. The three proteins of interest are Ap1g1 or gamma-adaptin; Ap2a2 or alpha-adaptin isoform C; and GGA2.

These cell lines were described in:

Dev Cell, 2010, 18: 324–331

Curr Biol 2012, 22: 1711–1716

J Cell Sci 2013, 126: 2102–2113

Curr Protoc Cell Biol, 2013, 61: 15.20.11–17

Cambridge Enterprise Limited is the exclusive licensor for the HeLa-Mitotrap cell lines. We have partnered with ECACC (The European Collection of Authenticated Cell Cultures; a Public Health England Culture Collection) to manage distribution of these cell lines on our behalf. Enquires to either organisation are welcomed.

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FcgRllb 131R receptor expressing cell line

29 September, 2011 | Cell lines Code: CL-0206
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CHO cells transfected to express human FcgRllb allotype 131R as a transmembrane protein with its native intracellular domain (including a polymorphism in the transmembrane region). Useful for investigation of the binding of recombinant antibodies to human Fc receptors.

Publications:

Armour et al. 2014. Eur J Immol. 44(3):905-14. PMID: 201343825.

Armour et al. 2014. PLoS One. 10;9(10). PMID: 25302805.

Harrison et al. 2012. J Pharm Biomed Anal. 7;63:23-8. PMID: 22366323.

Rohatgi et al. 2013. MBio. 27;4(5). PMID: 23982074.

Cambridge Enterprise Limited is the exclusive licensor this cell line. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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FcgRlla 131H receptor expressing cell line

29 September, 2011 | Cell lines Code: CL-0205
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CHO cells transfected to express human FcgRlla allotype 131H as a transmembrane protein with its native intracellular domain. Useful for investigation of the binding of recombinant antibodies to human Fc receptors.

Publications:

Armour et al. 2014. Eur J Immol. 44(3):905-14. PMID: 201343825.

Armour et al. 2014. PLoS One. 10;9(10). PMID: 25302805.

Cambridge Enterprise Limited is the exclusive licensor this cell line. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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FcgRlla 131R receptor expressing cell line

29 September, 2011 | Cell lines Code: CL-0204
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CHO cells transfected to express human FcgRlla allotype 131R as a transmembrane protein with its native intracellular domain. Useful for investigation of the binding of recombinant antibodies to human Fc receptors.

Publications:

Armour et al. 2014. Eur J Immol. 44(3):905-14. PMID: 201343825.

Armour et al. 2014. PLoS One. 10;9(10). PMID: 25302805.

Cambridge Enterprise Limited is the exclusive licensor this cell line. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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FcgRIIIa 158F/GPI receptor expressing cell line

29 September, 2011 | Cell lines Code: CL7
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CHO cells transfected to express human FcgRIIIa of the 158F allotype on their surface as glycosyl-phosphatidylinositol-anchored molecules useful for investigation of the binding of recombinant antibodies to human Fc receptors.

Publications:

Armour et al. 2010. J Immunol Methods. 31;354(1-2):20-33. PMID: 20138184.

Armour et al. 2014. Eur J Immol. 44(3):905-14. PMID: 201343825.

Armour et al. 2014. PLoS One. 10;9(10). PMID: 25302805.

Harrison et al. 2012. J Pharm Biomed Anal. 7;63:23-8. PMID: 22366323.

Rohatgi et al. 2013. MBio. 27;4(5). PMID: 23982074.

Cambridge Enterprise Limited is the exclusive licensor this cell line. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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FcgRIIIa 158V/GPI receptor expressing cell line

29 September, 2011 | Cell lines Code: CL6
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CHO cells transfected to express human FcgRIIIa of the 158V allotype on their surface as glycosyl-phosphatidylinositol-anchored molecules useful for investigation of the binding of recombinant antibodies to human Fc receptors.

Publications:

Armour et al. 2010. J Immunol Methods. 31;354(1-2):20-33. PMID: 20138184.

Armour et al. 2014. Eur J Immol. 44(3):905-14. PMID: 201343825.

Armour et al. 2014. PLoS One. 10;9(10). PMID: 25302805.

Harrison et al. 2012. J Pharm Biomed Anal. 7;63:23-8. PMID: 22366323.

Rohatgi et al. 2013. MBio. 27;4(5). PMID: 23982074.

Cambridge Enterprise Limited is the exclusive licensor this cell line. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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KARPAS 929 Human Myeloma cell line

20 September, 2011 | Cell lines Code: CL18
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KARPAS 929 Human Myeloma cell line, developed at the University of Cambridge, useful in oncology research.

Publications:

Karpas et al. (2005). Leuk. Lymphoma, 46(1), 101–112

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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KARPAS 417 Human Myeloma cell line

20 September, 2011 | Cell lines Code: CL17
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KARPAS 417 Human Myeloma cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Karpas et al. (2005). Leuk. Lymphoma, 46(1), 101–112

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Authenticated Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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KARPAS 25 Human Myeloma cell line

20 September, 2011 | Cell lines Code: CL16
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KARPAS 25 Human Myeloma cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Karpas et al. (2005). Leuk. Lymphoma, 46(1), 101–112

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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KARPAS 1272 Human Myeloma cell line

20 September, 2011 | Cell lines Code: CL15
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KARPAS 1272 Human Myeloma cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Karpas et al. (2005). Leuk. Lymphoma, 46(1), 101–112

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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KARPAS 707H Human Myeloma cell line

20 September, 2011 | Cell lines Code: CL3
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KARPAS 241 Human Monoblastic cell line

20 September, 2011 | Cell lines Code: CL20
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KARPAS 241 Human Monoblastic cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Immunopharmacology 1982, 5(2) 123–7

Brit J Haematology 1980, 44, 415–424

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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  • In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. A backup of your data will be held but only authorised individuals will be able to access your data. If you would like your data to be removed, please email support@thewebkitchen.co.uk.

KARPAS 620 Human Plasma Cell Leukaemia cell line

20 September, 2011 | Cell lines Code: CL14
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KARPAS 620 Human Plasma Cell Leukemia cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Nacheva et al. (1990). Br J Haematol 74, 70–76

Drexler and Matsuo (2000). Leuk Res 24, 681–703

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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KARPAS 45 Human T-cell Leukaemia cell line

20 September, 2011 | Cell lines Code: CL13
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KARPAS 45 Human T-cell Leukemia cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Smith et al. (1973). Lancet 301, 74–77

Borkhardt et al. (1997) Oncogene 14, 195–202

Drexler et al. (2004). Leukemia 18, 227–232

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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  • In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. A backup of your data will be held but only authorised individuals will be able to access your data. If you would like your data to be removed, please email support@thewebkitchen.co.uk.

KARPAS 353 Human B-cell Leukaemia cell line

20 September, 2011 | Cell lines Code: CL21
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KARPAS 353 Human B-cell Leukaemia cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Nacheva et al. (1993) Blood 82, 231–240

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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  • In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. A backup of your data will be held but only authorised individuals will be able to access your data. If you would like your data to be removed, please email support@thewebkitchen.co.uk.

KARPAS 231 Human B-cell Leukaemia cell line

20 September, 2011 | Cell lines Code: CL9
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KARPAS 231 Human B-cell Leukaemia cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Nacheva et al. (1993). Blood 82, 231–240

Galieque Zouitina et al. (1996). Leukemia 10, 579–587

Willis et al. (1997). Blood 90, 2456–2464

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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  • In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. A backup of your data will be held but only authorised individuals will be able to access your data. If you would like your data to be removed, please email support@thewebkitchen.co.uk.

KARPAS 1718 Human Splenic Lymphoma cell line

20 September, 2011 | Cell lines Code: CL22
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KARPAS 1718 Human Splenic Lymphoma cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Ota et al (2004) Cancer Res. 64 (9), 3087-3095.

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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  • In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. A backup of your data will be held but only authorised individuals will be able to access your data. If you would like your data to be removed, please email support@thewebkitchen.co.uk.

KARPAS 299 Human Non-Hodgkin’s Ki-positive Large Cell Lymphoma cell line

20 September, 2011 | Cell lines Code: CL10
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KARPAS 299 Human Non-Hodgkin’s Ki-positive Large Cell Lymphoma cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Ficsher et al. (1988). Blood 72, 234–240

Wolke et al. (2006). Int J Mol Med 17, 275–278

Drexler et al. (2004). Leukemia 18, 1569–1571

Fillmore et al. (2002). FEBS Lett. 522, 183-188

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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KARPAS 384 Human T-cell non-Hodgkin’s Lymphoma cell line

20 September, 2011 | Cell lines Code: CL11
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KARPAS 384 Human T-cell non-Hodgkin’s Lymphoma cell line useful in oncology research, developed at the University of Cambridge.

Publications:

Dyer et al. (1993). Leukemia, 7, 1047–1053

Cambridge Enterprise Limited is the exclusive licensor for the Karpas cell line portfolio. We have partnered with ECACC (The European Collection of Cell Cultures; a Public Health England Culture Collection) to manage distribution of the majority of these cells on our behalf. Enquires to either organisation are welcomed.

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Enquiry for KARPAS 384 Human T-cell non-Hodgkin’s Lymphoma cell line

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To find out more about how this website collects your personal data see www.enterprise.cam.ac.uk/about-us/information-compliance/data-protection/core-privacy-notices/website-users-use-personal-information/
  • In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. A backup of your data will be held but only authorised individuals will be able to access your data. If you would like your data to be removed, please email support@thewebkitchen.co.uk.