Hepatoblast Organoids – A novel 3D primary cellular model for drug screening and cell based therapy in liver

Ref No: Val-3636-18

University of Cambridge researchers have generated a unique human hepatoblast organoid system that can be maintained for more than a year in each line. The lines expand exponentially, demonstrate transcriptional and genomic stability, express key functional hepatic proteins and can be frozen down for long term storage. The HBO can be treated in vitro to differentiate towards cholangiocyte or hepatocyte lineages on demand. The HBO system offers two exciting areas of commercialisation: drug screening and cell-based therapy. The team are seeking a commercial partner for collaboration and development of this technology.

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