Enhancing the efficacy and persistence of adoptive T cell therapies

Ref No: Joh-3155 & Joh-3733-19


Apollo Therapeutics, working closely with Prof. Randall Johnson and his team in the Department of Physiology, Development & Neuroscience at the University of Cambridge have developed a small molecule that promotes memory T cell populations – octyl S-2-hydroxyglutarate – and have demonstrated applicability to human CAR-T systems.


Licensing opportunity: octyl S-2-hydroxyglutarate

  • Promotes memory T cell populations, conferring persistence and proliferation that translates into enhanced anti-tumour efficacy
  • Characterised in mouse and human systems
  • Fully compatible with human CAR-T lentiviral transduction protocols
  • Opportunity for clinical differentiation


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