Reagents
Cell lines
Our reagents in Cell lines are listed below.
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Human alpha synuclein cell lines
PC12 Tet-On cells expressing human α-synuclein (HA and his tagged); one cell line expresses wild-type α-synuclein and two other cell lines express one of two mutant forms of human α-synuclein, either A53T or A30P. Both of these two mutations are responsible for certain rare familial forms of Parkinson’s disease.
These cells are first described in: Alpha-Synuclein is degraded by both autophagy and the proteasome. Webb JL et al, J Biol Chem (2003) 278 (27):25009.
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FcgRllb 131R receptor expressing cell line
CHO cells transfected to express human FcgRllb allotype 131R as a transmembrane protein with its native intracellular domain (including a polymorphism in the transmembrane region). Useful for investigation of the binding of recombinant antibodies to human Fc receptors.
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FcgRlla 131H receptor expressing cell line
CHO cells transfected to express human FcgRlla allotype 131H as a transmembrane protein with its native intracellular domain. Useful for investigation of the binding of recombinant antibodies to human Fc receptors.
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FcgRlla 131R receptor expressing cell line
CHO cells transfected to express human FcgRlla allotype 131R as a transmembrane protein with its native intracellular domain. Useful for investigation of the binding of recombinant antibodies to human Fc receptors.
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FcgRIIIa 158F/GPI receptor expressing cell line
CHO cells transfected to express human FcyRIIIa of the 158F allotype on their surface as glycosyl-phosphatidylinositol-anchored molecules useful for investigation of the binding of recombinant antibodies to human Fc receptors.
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FcgRIIIa 158V/GPI receptor expressing cell line
CHO cells transfected to express human FcyRIIIa of the 158V allotype on their surface as glycosyl-phosphatidylinositol-anchored molecules useful for investigation of the binding of recombinant antibodies to human Fc receptors.
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KARPAS 707 Human Myeloma cell line
Human Myeloma cell line useful in oncology research.
Publications:
Science 1982, 216, 997-999
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KARPAS 929 Human Myeloma cell line
Human Myeloma cell line useful in oncology research.
Publications:
Karpas et al., (2005) Studies of four new human myeloma cell lines. Leukemia & Lymphoma 46(1): 101-112.http://www.ingentaconnect.com/
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KARPAS 417 Human Myeloma cell line
Human Myeloma cell line useful in oncology research.
Publications:
Karpas et al., (2005) Studies of four new human myeloma cell lines. Leukemia & Lymphoma 46(1): 101-112.http://www.ingentaconnect.com/content/apl/glal?
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KARPAS 25 Human Myeloma cell line
Human Myeloma cell line useful in oncology research.
Publications:
Karpas et al., (2005) Studies of four new human myeloma cell lines. Leukemia & Lymphoma 46(1): 101-112.http://www.ingentaconnect.com/content/apl/glal?
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KARPAS 1272 Human Myeloma cell line
Human Myeloma cell line useful in oncology research.
Publications:
Karpas et al., (2005) Studies of four new human myeloma cell lines. Leukemia & Lymphoma 46(1): 101-112.http://www.ingentaconnect.com/content/apl/glal?
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KARPAS 707H Human Myeloma cell line
Human myeloma cell line suitable for the generation of stable human hybridomas for the creation of fully human monoclonal antibodies.
Publications:
Karpas et al. (2001) Proc. Natn Acad. Sci. 98 1799-1804. http://www.pnas.org/
Vaisbourd et al. (2001) Hybridoma & Hybridomics 20. 287-292 -
KARPAS 241 Human Monoblastic cell line
Human Monoblastic cell line useful in oncology research.
Publications:
Immunopharmacology 1982, 5(2) 123-7; Brit J Haematology 1980, 44, 415-424
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KARPAS 620 Human Plasma Cell Leukaemia cell line
Human Plasma Cell Leukemia cell line useful in oncology research.
Publications:
Nacheva et al., Br J Haematol 74: 70-76 (1990)
Review: Drexler & Matsuo, Leuk Res 24: 681-703 (2000). http://www.lrjournal.com/ -
KARPAS 45 Human T-Cell Leukaemia cell line
Human T-Cell Leukemia cell line useful in oncology research.
Publications:
Karpas et al., Leuk Res 1: 35-49 (1977)
Smith et al., Lancet : 74-77 (1973)
Borkhard et al., Oncogene 14: 195-202 (1997)
review: Drexler et al., Leukemia 18: 227-232 (2004). http://www.nature.com/leu/index.html -
KARPAS 353 Human B-Cell Leukaemia cell line
KARPAS 353 Human B-Cell Leukaemia cell line useful in oncology research.
Publications:
Blood 1993, 82(1), 231-40. http://bloodjournal.hematologylibrary.org/
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KARPAS 231 Human B-Cell Leukaemia cell line
KARPAS 231 Human B-Cell Leukaemia cell line useful in oncology research.
Publications:
Nacheva et al., Blood 82: 231-240 (1993). http://bloodjournal.hematologylibrary.org/
Galieque Zouitina et al., Leukemia 10: 579-587 (1996)
Willis et al., Blood 90: 2456-2464 (1997). http://bloodjournal.hematologylibrary.org/ -
KARPAS 1718 Human Splenic Lymphoma cell line
KARPAS 1718 Human Splenic Lymphoma cell line useful in oncology research.
Publications:
Cancer Research 2004 64 9 3087; http://cancerres.aacrjournals.org/
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KARPAS 299 Human Non-Hodgkin's Ki-positive Large Cell Lymphoma cell line
KARPAS 299 Human Non-Hodgkin's Ki-positive Large Cell Lymphoma cell line useful in oncology research.
Publications:
Fisher et al., Blood 72: 234-240 (1988). http://bloodjournal.hematologylibrary.org/
Mason et al., Br J Haematol 74: 161-168 (1990)
Review: Drexler et al., Leukemia 18: 1569-1571 (2004). http://www.nature.com/leu/index.html -
KARPAS 384 Human T-cell non-Hodgkin's Lymphoma cell line
KARPAS 384 Human T-cell non-Hodgkin's Lymphoma cell line useful in oncology research.
Publications:
Dyer et al. (1993) A new human T-cell lymphoma cell line (KARPAS 384) of the T-cell receptor gamma/delta lineage with translocation t(7:14) (p13;q11.2), Leukemia 7 1047-1053
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KARPAS 422 Human B-Cell Non-Hodgkin's Lymphoma cell line
KARPAS 422 Human B-Cell Non-Hodgkin's Lymphoma cell line useful in oncology research.
Publications:
Dyer et al., Blood 75: 709-714 (1990). http://bloodjournal.hematologylibrary.org/
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KARPAS 1106P Human B-Cell Non-Hodgkin's Lymphoma cell line
KARPAS 1106P Human B-Cell Non-Hodgkin's Lymphoma cell line useful in oncology research.
Publications:
Nacheva et al., Blood 84: 3422-3428 (1994). http://bloodjournal.hematologylibrary.org/
Tamura et al., Int J Cancer 78: 100-105 (1998)
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PC12 (rat phaeochromocytoma) HD-Q74 (lines 10 and 1b)
Inducible lines in PC12 (rat phaeochromocytoma) cells which express a GFP-tagged exon 1 fragment of the HD gene with 74 glutamine repeats (cell lines 10 and 1b), driven by a doxycycline (dox)-dependent Tet-On promoter. Useful in in-vitro assay development for neurodegenerative diseases.
Publications:
Wyttenbach et al, Human Mol Genet (2001)10: 1829-1845. http://hmg.oxfordjournals.org/
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PC12 (rat phaeochromocytoma) HD-Q23 (lines 14 and 7)
Inducible lines in PC12 (rat phaeochromocytoma) cells which express a GFP-tagged exon 1 fragment of the HD gene with 23 glutamine repeats (cell lines 14 and 7), driven by a doxycycline (dox)-dependent Tet-On promoter. Useful in in-vitro assay development for neurodegenerative diseases.
Publications:
Wyttenbach et al, Human Mol Genet (2001)10: 1829-1845. http://hmg.oxfordjournals.org/
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W-12 cell line
Human keratinocyte cell line useful in research related to human papillomavirus type 16 (HPV16) and cervical carcinoma.
This reagent is available to license for internal research use only.