Human alpha synuclein cell lines
PC12 Tet-On cells expressing human α-synuclein (HA and his tagged); one cell line expresses wild-type α-synuclein and two other cell lines express one of two mutant forms of human α-synuclein, either A53T or A30P. Both of these two mutations are responsible for certain rare familial forms of Parkinson’s disease.
These cells are first described in: Alpha-Synuclein is degraded by both autophagy and the proteasome. Webb JL et al, J Biol Chem (2003) 278 (27):25009.