Our researchers have identified the earliest known marker for DNA damage. Phosphorylation of residue Thr51 of protein HP1β occurs within minutes of the onset of DNA damage. A robust, specific polyclonal antibody to the phosphorylated form of this protein has been developed which is an effective biomarker for DNA damage. This has excellent potential for use as a biomarker in clinical applications such as the diagnosis, prognosis and predictive response of individuals to cancer therapy.

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