Cell Culture Model for Huntington's Disease
Reference number: Rub-1856-07
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Two stable inducible rat phaeochromocytoma (PC12) cell lines expressing GFP-tagged exon 1 of the Huntington gene with either 23 or 74 glutamine repeats (PC12 HD-Q23 or PC HD-Q74), driven by a doxycycline-dependent Tet-On promoter. These cell lines can be used for in vitro studies to evaluate compounds to treat Huntington's disease.